NAU publications by CHER
Faculty & staff publications
NAU faculty and staff have the opportunity to publish their findings and knowledge as authors. CHER has many researchers that have been cited multiple times in major publications for their great work. The Center for Health Equity Research has accumulated all faculty publications into one, easy to navigate database.
Please type in a key word or author LAST name to search
Magdaleno, Carina; House, Trenton; Pawar, Jogendra S; Carvalho, Sophia; Rajasekaran, Narendiran; Varadaraj, Archana Fibronectin assembly regulates lumen formation in breast acini Journal Article Journal of Cellular Biochemistry, 2021. @article{Magdaleno2021, title = {Fibronectin assembly regulates lumen formation in breast acini}, author = {Carina Magdaleno and Trenton House and Jogendra S. Pawar and Sophia Carvalho and Narendiran Rajasekaran and Archana Varadaraj}, url = {https://doi.org/10.1002/jcb.29885}, doi = {10.1002/jcb.29885}, year = {2021}, date = {2021-01-13}, journal = {Journal of Cellular Biochemistry}, abstract = {Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic. |
Coulter K., Sabo Martínez Chisholm Gonzalez Bass Zavala Villalobos Garcia Levy Slack S D K K S E D T J A Study and Analysis of the Treatment of Mexican Unaccompanied Minors by Customs and Border Protection Journal Article Journal on Migration and Human Security, 2020. @article{Coulter2020, title = {A Study and Analysis of the Treatment of Mexican Unaccompanied Minors by Customs and Border Protection}, author = {Coulter, K., Sabo, S., Martínez, D., Chisholm, K., Gonzalez, K., Bass Zavala, S., Villalobos E., Garcia D. Levy, T., Slack, J.}, url = {https://journals.sagepub.com/doi/10.1177/2331502420915898}, doi = {10.1177/2331502420915898}, year = {2020}, date = {2020-04-22}, journal = {Journal on Migration and Human Security}, abstract = {The routine human rights abuses and due process violations of unaccompanied alien children (UAC) by US Customs and Border Protection (CBP) have contributed to a mounting humanitarian and legal crisis along the US–Mexico border. In the United States, the treatment of UAC is governed by laws, policies, and standards drawn from the Flores Settlement, the Trafficking Victims Protection Reauthorization Act (TVPRA), and CBP procedures and directives, which are intended to ensure UAC’s protection, well-being, and ability to pursue relief from removal, such as asylum. As nongovernmental organizations and human rights groups have documented, however, CBP has repeatedly violated these legal standards and policies, and subjected UAC to abuses and rights violations. This article draws from surveys of 97 recently deported Mexican UAC, which examine their experiences with US immigration authorities. The study finds that Mexican UAC are detained in subpar conditions, are routinely not screened for fear of return to their home countries or for human trafficking, and are not sufficiently informed about the deportation process. The article recommends that CBP should take immediate steps to improve the treatment of UAC, that CBP and other entities responsible for the care of UAC be monitored to ensure their compliance with US law and policy, and that Mexican UAC be afforded the same procedures and protection under the TVPRA as UAC from noncontiguous states.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The routine human rights abuses and due process violations of unaccompanied alien children (UAC) by US Customs and Border Protection (CBP) have contributed to a mounting humanitarian and legal crisis along the US–Mexico border. In the United States, the treatment of UAC is governed by laws, policies, and standards drawn from the Flores Settlement, the Trafficking Victims Protection Reauthorization Act (TVPRA), and CBP procedures and directives, which are intended to ensure UAC’s protection, well-being, and ability to pursue relief from removal, such as asylum. As nongovernmental organizations and human rights groups have documented, however, CBP has repeatedly violated these legal standards and policies, and subjected UAC to abuses and rights violations. This article draws from surveys of 97 recently deported Mexican UAC, which examine their experiences with US immigration authorities. The study finds that Mexican UAC are detained in subpar conditions, are routinely not screened for fear of return to their home countries or for human trafficking, and are not sufficiently informed about the deportation process. The article recommends that CBP should take immediate steps to improve the treatment of UAC, that CBP and other entities responsible for the care of UAC be monitored to ensure their compliance with US law and policy, and that Mexican UAC be afforded the same procedures and protection under the TVPRA as UAC from noncontiguous states. |
Ortega, María Isabel; Sabo, Samantha; Gallegos, Patricia Aranda; Zapien, Jill Eileen Guernsey De; Zapien, Antonio; Abril, Gloria Elena Portillo; Rosales, Cecilia Agribusiness, Corporate Social Responsibility, and Health of Agricultural Migrant Workers Journal Article Frontiers in Public Health, 4 (54), pp. 1-10, 2016. @article{Ortega2016, title = {Agribusiness, Corporate Social Responsibility, and Health of Agricultural Migrant Workers}, author = {María Isabel Ortega and Samantha Sabo and Patricia Aranda Gallegos and Jill Eileen Guernsey De Zapien and Antonio Zapien and Gloria Elena Portillo Abril and Cecilia Rosales}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27066471}, doi = {10.3389/fpubh.2016.00054}, year = {2016}, date = {2016-03-29}, journal = {Frontiers in Public Health}, volume = {4}, number = {54}, pages = {1-10}, abstract = {BACKGROUND: Living conditions and health of migrant farmworkers could benefit from a health promotion model based on corporate social responsibility (CSR). OBJECTIVE: To understand how Mexican agribusiness owners and general managers view and practice CSR. METHODS: We interviewed 8 agribusiness owners/managers and 233 farmworkers using open-ended interviews and gathered anthropometrical data of 133 children from farmworkers families. To guide our analysis and discussion, we followed the two-dimension model of CSR proposed by Quazi and O'Brien. RESULTS: According to interviewee responses, mean percentage of agreement with CSR concept was 77.4%, with a range of 54-85.7%. Main health-related issues among farmworkers were infectious diseases, crowding, and access to health-care services; there were acute cases of undernutrition among farmworkers' children and diets were of poor quality. DISCUSSION: Agribusiness owners and managers understand and practice CSR according to a wide and modern view, which contradicts with farmworkers' living conditions and health. Quazi and O'Brien model should consider the social context, in which it is analyzed, and the social manifestations of community development as a tool for further analysis on the perceptions and actions of entrepreneurs.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Living conditions and health of migrant farmworkers could benefit from a health promotion model based on corporate social responsibility (CSR). OBJECTIVE: To understand how Mexican agribusiness owners and general managers view and practice CSR. METHODS: We interviewed 8 agribusiness owners/managers and 233 farmworkers using open-ended interviews and gathered anthropometrical data of 133 children from farmworkers families. To guide our analysis and discussion, we followed the two-dimension model of CSR proposed by Quazi and O'Brien. RESULTS: According to interviewee responses, mean percentage of agreement with CSR concept was 77.4%, with a range of 54-85.7%. Main health-related issues among farmworkers were infectious diseases, crowding, and access to health-care services; there were acute cases of undernutrition among farmworkers' children and diets were of poor quality. DISCUSSION: Agribusiness owners and managers understand and practice CSR according to a wide and modern view, which contradicts with farmworkers' living conditions and health. Quazi and O'Brien model should consider the social context, in which it is analyzed, and the social manifestations of community development as a tool for further analysis on the perceptions and actions of entrepreneurs. |
Gallegos, Patricia A; Velez, Maria Ortega I; Rosales, Cecilia; de Zapien, Jill; Sabo, Samantha; Zapien, Antonio Migracion y atención a la salud de los Jornalero agricolas Book Chapter In Alternativas en la crisis para la transformación de las políticas sociales en México,, Chapter 7, El Colegio de Sonora, CIAD, Fundación Konrad Adenauer, 2013, ISBN: 978-607-7900-11-5. @inbook{Gallegos2013, title = {Migracion y atención a la salud de los Jornalero agricolas}, author = {Patricia A Gallegos and Maria Ortega I Velez and Cecilia Rosales and Jill de Zapien and Samantha Sabo and Antonio Zapien}, url = {http://alamo.colson.edu.mx:8085/sitios/CESS/091020_frutosTrabajo/frutos_archivos/ArandaOrtega2013_Migracion%20y%20atencion.pdf}, isbn = {978-607-7900-11-5}, year = {2013}, date = {2013-01-01}, booktitle = {In Alternativas en la crisis para la transformación de las políticas sociales en México,}, publisher = {El Colegio de Sonora, CIAD, Fundación Konrad Adenauer}, chapter = {7}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } |
2021 |
Magdaleno, Carina; House, Trenton; Pawar, Jogendra S; Carvalho, Sophia; Rajasekaran, Narendiran; Varadaraj, Archana Fibronectin assembly regulates lumen formation in breast acini Journal Article Journal of Cellular Biochemistry, 2021. @article{Magdaleno2021, title = {Fibronectin assembly regulates lumen formation in breast acini}, author = {Carina Magdaleno and Trenton House and Jogendra S. Pawar and Sophia Carvalho and Narendiran Rajasekaran and Archana Varadaraj}, url = {https://doi.org/10.1002/jcb.29885}, doi = {10.1002/jcb.29885}, year = {2021}, date = {2021-01-13}, journal = {Journal of Cellular Biochemistry}, abstract = {Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic. |
2020 |
Coulter K., Sabo Martínez Chisholm Gonzalez Bass Zavala Villalobos Garcia Levy Slack S D K K S E D T J A Study and Analysis of the Treatment of Mexican Unaccompanied Minors by Customs and Border Protection Journal Article Journal on Migration and Human Security, 2020. @article{Coulter2020, title = {A Study and Analysis of the Treatment of Mexican Unaccompanied Minors by Customs and Border Protection}, author = {Coulter, K., Sabo, S., Martínez, D., Chisholm, K., Gonzalez, K., Bass Zavala, S., Villalobos E., Garcia D. Levy, T., Slack, J.}, url = {https://journals.sagepub.com/doi/10.1177/2331502420915898}, doi = {10.1177/2331502420915898}, year = {2020}, date = {2020-04-22}, journal = {Journal on Migration and Human Security}, abstract = {The routine human rights abuses and due process violations of unaccompanied alien children (UAC) by US Customs and Border Protection (CBP) have contributed to a mounting humanitarian and legal crisis along the US–Mexico border. In the United States, the treatment of UAC is governed by laws, policies, and standards drawn from the Flores Settlement, the Trafficking Victims Protection Reauthorization Act (TVPRA), and CBP procedures and directives, which are intended to ensure UAC’s protection, well-being, and ability to pursue relief from removal, such as asylum. As nongovernmental organizations and human rights groups have documented, however, CBP has repeatedly violated these legal standards and policies, and subjected UAC to abuses and rights violations. This article draws from surveys of 97 recently deported Mexican UAC, which examine their experiences with US immigration authorities. The study finds that Mexican UAC are detained in subpar conditions, are routinely not screened for fear of return to their home countries or for human trafficking, and are not sufficiently informed about the deportation process. The article recommends that CBP should take immediate steps to improve the treatment of UAC, that CBP and other entities responsible for the care of UAC be monitored to ensure their compliance with US law and policy, and that Mexican UAC be afforded the same procedures and protection under the TVPRA as UAC from noncontiguous states.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The routine human rights abuses and due process violations of unaccompanied alien children (UAC) by US Customs and Border Protection (CBP) have contributed to a mounting humanitarian and legal crisis along the US–Mexico border. In the United States, the treatment of UAC is governed by laws, policies, and standards drawn from the Flores Settlement, the Trafficking Victims Protection Reauthorization Act (TVPRA), and CBP procedures and directives, which are intended to ensure UAC’s protection, well-being, and ability to pursue relief from removal, such as asylum. As nongovernmental organizations and human rights groups have documented, however, CBP has repeatedly violated these legal standards and policies, and subjected UAC to abuses and rights violations. This article draws from surveys of 97 recently deported Mexican UAC, which examine their experiences with US immigration authorities. The study finds that Mexican UAC are detained in subpar conditions, are routinely not screened for fear of return to their home countries or for human trafficking, and are not sufficiently informed about the deportation process. The article recommends that CBP should take immediate steps to improve the treatment of UAC, that CBP and other entities responsible for the care of UAC be monitored to ensure their compliance with US law and policy, and that Mexican UAC be afforded the same procedures and protection under the TVPRA as UAC from noncontiguous states. |
2016 |
Ortega, María Isabel; Sabo, Samantha; Gallegos, Patricia Aranda; Zapien, Jill Eileen Guernsey De; Zapien, Antonio; Abril, Gloria Elena Portillo; Rosales, Cecilia Agribusiness, Corporate Social Responsibility, and Health of Agricultural Migrant Workers Journal Article Frontiers in Public Health, 4 (54), pp. 1-10, 2016. @article{Ortega2016, title = {Agribusiness, Corporate Social Responsibility, and Health of Agricultural Migrant Workers}, author = {María Isabel Ortega and Samantha Sabo and Patricia Aranda Gallegos and Jill Eileen Guernsey De Zapien and Antonio Zapien and Gloria Elena Portillo Abril and Cecilia Rosales}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27066471}, doi = {10.3389/fpubh.2016.00054}, year = {2016}, date = {2016-03-29}, journal = {Frontiers in Public Health}, volume = {4}, number = {54}, pages = {1-10}, abstract = {BACKGROUND: Living conditions and health of migrant farmworkers could benefit from a health promotion model based on corporate social responsibility (CSR). OBJECTIVE: To understand how Mexican agribusiness owners and general managers view and practice CSR. METHODS: We interviewed 8 agribusiness owners/managers and 233 farmworkers using open-ended interviews and gathered anthropometrical data of 133 children from farmworkers families. To guide our analysis and discussion, we followed the two-dimension model of CSR proposed by Quazi and O'Brien. RESULTS: According to interviewee responses, mean percentage of agreement with CSR concept was 77.4%, with a range of 54-85.7%. Main health-related issues among farmworkers were infectious diseases, crowding, and access to health-care services; there were acute cases of undernutrition among farmworkers' children and diets were of poor quality. DISCUSSION: Agribusiness owners and managers understand and practice CSR according to a wide and modern view, which contradicts with farmworkers' living conditions and health. Quazi and O'Brien model should consider the social context, in which it is analyzed, and the social manifestations of community development as a tool for further analysis on the perceptions and actions of entrepreneurs.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Living conditions and health of migrant farmworkers could benefit from a health promotion model based on corporate social responsibility (CSR). OBJECTIVE: To understand how Mexican agribusiness owners and general managers view and practice CSR. METHODS: We interviewed 8 agribusiness owners/managers and 233 farmworkers using open-ended interviews and gathered anthropometrical data of 133 children from farmworkers families. To guide our analysis and discussion, we followed the two-dimension model of CSR proposed by Quazi and O'Brien. RESULTS: According to interviewee responses, mean percentage of agreement with CSR concept was 77.4%, with a range of 54-85.7%. Main health-related issues among farmworkers were infectious diseases, crowding, and access to health-care services; there were acute cases of undernutrition among farmworkers' children and diets were of poor quality. DISCUSSION: Agribusiness owners and managers understand and practice CSR according to a wide and modern view, which contradicts with farmworkers' living conditions and health. Quazi and O'Brien model should consider the social context, in which it is analyzed, and the social manifestations of community development as a tool for further analysis on the perceptions and actions of entrepreneurs. |
2013 |
Gallegos, Patricia A; Velez, Maria Ortega I; Rosales, Cecilia; de Zapien, Jill; Sabo, Samantha; Zapien, Antonio Migracion y atención a la salud de los Jornalero agricolas Book Chapter In Alternativas en la crisis para la transformación de las políticas sociales en México,, Chapter 7, El Colegio de Sonora, CIAD, Fundación Konrad Adenauer, 2013, ISBN: 978-607-7900-11-5. @inbook{Gallegos2013, title = {Migracion y atención a la salud de los Jornalero agricolas}, author = {Patricia A Gallegos and Maria Ortega I Velez and Cecilia Rosales and Jill de Zapien and Samantha Sabo and Antonio Zapien}, url = {http://alamo.colson.edu.mx:8085/sitios/CESS/091020_frutosTrabajo/frutos_archivos/ArandaOrtega2013_Migracion%20y%20atencion.pdf}, isbn = {978-607-7900-11-5}, year = {2013}, date = {2013-01-01}, booktitle = {In Alternativas en la crisis para la transformación de las políticas sociales en México,}, publisher = {El Colegio de Sonora, CIAD, Fundación Konrad Adenauer}, chapter = {7}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } |